Phenotypes Associated with This Genotype

Genotype
MGI:7262906

• Allelic Composition: Clec2h^tm1.1Apma/Clec2h^tm1.1Apma; Rag1^tm1Mom/Rag1^tm1Mom
• Genetic Background: B6.Cg-Rag1^tm1Mom Clec2h^tm1.1Apma

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney capillary morphology ( J:322835 )

• kidneys show an increase in endocapillary proliferation

kidney inflammation ( J:322835 )

• kidneys show increased presence of IL-12 and IFN-gamma

• kidneys exhibit an extensive periglomerular accumulation of CD45+ cells, consisting of CD11c+, F4/80+, and Nkp46+ cells, indicating inflammation

abnormal renal glomerulus morphology ( J:322835 )

• glomerular lesions indicative of mild proliferative glomerulopathy and areas of glomerular fibrosis

increased mesangial cell number ( J:322835 )

• an increase in the presence of mesangial cellularity

glomerulosclerosis ( J:322835 )

• glomerulosclerosis or focal segmental sclerosis

glomerular crescent ( J:322835 )

renal glomerulus fibrosis ( J:322835 )

• areas of glomerular fibrosis

renal interstitial fibrosis ( J:322835 )

renal tubule atrophy ( J:322835 )

adipose tissue

abnormal adipose tissue amount ( J:322835 )

• abdominal lipid weight is increased compared to that in single Rag1 mutant homozygotes, but to a lesser extent than in single Clec2h mutant homozygotes

cardiovascular system

abnormal kidney capillary morphology ( J:322835 )

• kidneys show an increase in endocapillary proliferation

growth/size/body

decreased body weight ( J:322835 )

• body weight is lower than in single Rag1 mutant homozygotes

immune system

kidney inflammation ( J:322835 )

• kidneys show increased presence of IL-12 and IFN-gamma

• kidneys exhibit an extensive periglomerular accumulation of CD45+ cells, consisting of CD11c+, F4/80+, and Nkp46+ cells, indicating inflammation

cellular

increased mesangial cell number ( J:322835 )

• an increase in the presence of mesangial cellularity