Phenotypes for Rad51ap2 MGI:6888119 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rad51ap2^em1Qsh/Rad51ap2^em1Qsh
Genetic Background	involves: C57BL/6J * DBA/2J

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad51ap2^em1Qsh mutation (0 available); any Rad51ap2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:321708 )

N	• crossover formation and meiosis in oocytes is normal

oligozoospermia ( J:321708 )

abnormal X-Y chromosome synapsis during male meiosis ( J:321708 )

• increased frequency of XY dissociation in meiotic metaphase I spermatocytes with reduced crossover and compromised double-strand break repair in the pseudoautosomal region

arrest of male meiosis ( J:321708 )

• unaligned chromosomes and reduced number of post-meiotic germ cells

increased male germ cell apoptosis ( J:321708 )

decreased testis weight ( J:321708 )

endocrine/exocrine glands

decreased testis weight ( J:321708 )

cellular

oligozoospermia ( J:321708 )

abnormal X-Y chromosome synapsis during male meiosis ( J:321708 )

• increased frequency of XY dissociation in meiotic metaphase I spermatocytes with reduced crossover and compromised double-strand break repair in the pseudoautosomal region

arrest of male meiosis ( J:321708 )

• unaligned chromosomes and reduced number of post-meiotic germ cells

increased male germ cell apoptosis ( J:321708 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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