Phenotypes Associated with This Genotype

Genotype
MGI:6887995

• Allelic Composition: Drosha^tm1Litt/Drosha^tm1Litt; Tg(Six2-EGFP/cre)1Amc/0
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased kidney apoptosis ( J:321428 )

• increased apoptosis of cortical and central mesenchymal and epithelial cells

• normal apoptosis of stromal cells

abnormal kidney morphology ( J:321428 )

• increase in stromal tissue in newborns

polycystic kidney ( J:321428 )

• cystic dilation of renal tubules in newborns

abnormal renal glomerulus morphology ( J:321428 )

• no mature glomeruli in E18.5 embryos and in newborns

decreased renal glomerulus number ( J:321428 )

• reduced number of glomeruli in E16.5 embryos

abnormal kidney development ( J:321428 )

• reduced number of S-shaped bodies in E13.5 embryos with further reduction at E16.5

• immature comma- and S-shaped bodies in E16.5 embryos

• no mature glomeruli in E18.5 embryos and in newborns

abnormal nephrogenic zone morphology ( J:321428 )

• thin and discontinuous cortical nephrogenic zone

renal hypoplasia ( J:321428 )

• smaller kidneys with reduced tubular structures in newborns

dilated renal tubule ( J:321428 )

• cystic dilation in newborns

absent kidney ( J:321428 )

• at least one absent kidney in 36% of E16.5 embryos, both absent in 6.5%

mortality/aging

perinatal lethality, complete penetrance ( J:321428 )

• early perinatal mortality: no offspring beyond weaning stage

cellular

increased kidney apoptosis ( J:321428 )

• increased apoptosis of cortical and central mesenchymal and epithelial cells

• normal apoptosis of stromal cells

behavior/neurological

decreased food intake ( J:321428 )

• smaller milk spot in newborns

decreased locomotor activity ( J:321428 )

• in newborns

cardiovascular system

congestive heart failure ( J:321428 )

• causing death within hours of birth

homeostasis/metabolism

cyanosis ( J:321428 )

• in newborns

pulmonary edema ( J:321428 )

• causing death within hours of birth

growth/size/body

polycystic kidney ( J:321428 )

• cystic dilation of renal tubules in newborns

respiratory system

pulmonary edema ( J:321428 )

• causing death within hours of birth

respiratory distress ( J:321428 )

• gasping in newborns