Phenotypes Associated with This Genotype

Genotype
MGI:6887991

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(CAG-YFP/DROSHA*E1147K)Gess}/Gt(ROSA)26Sor^{tm1.1(CAG-YFP/DROSHA*E1147K)Gess}; Tg(Six2-EGFP/cre)1Amc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased kidney apoptosis ( J:321428 )

• increased apoptosis of epithelial cells and in nephrogenic zone

growth/size/body

postnatal growth retardation ( J:321428 )

• severe growth retardation

homeostasis/metabolism

increased urine protein level ( J:321428 )

• extensive protein deposits in kidney tubules by age P28

renal/urinary system

increased kidney apoptosis ( J:321428 )

• increased apoptosis of epithelial cells and in nephrogenic zone

increased urine protein level ( J:321428 )

• extensive protein deposits in kidney tubules by age P28

glomerulosclerosis ( J:321428 )

• increasing with age

abnormal nephrogenic zone morphology ( J:321428 )

• reduced and patchy Six2, absent Sited1 and early loss of Wt1 expression in E16.5 embryos

renal hypoplasia ( J:321428 )

• smaller kidneys

abnormal renal tubule morphology ( J:321428 )

• severely impaired tubular maturation

absent kidney ( J:321428 )

• at least one absent kidney in 23% of E16.5 embryos, both absent in 1.8%

mortality/aging

mortality/aging ( J:321428 )

N • viable; survive from 38 to 283 days

neoplasm

neoplasm ( J:321428 )

N • no kidney tumor development in mice up to 283 days old