Phenotypes Associated with This Genotype

Genotype
MGI:6827448

• Allelic Composition: Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^tm1(EYFP)Cos; Pax7^{tm1(cre/ERT2)Gaka}/Pax7^{tm1(cre/ERT2)Gaka}; Paxbp1^tm1.1Nju/Paxbp1^tm1.1Nju
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial morphology ( J:304562 )

• fragmented mitochondria, largely restricted to perinuclear region, lacking interconnecting tubular network in activated muscle stem cells

abnormal respiratory electron transport chain ( J:304562 )

• defective cellular respiration and glycolysis

abnormal mitochondrial ATP synthesis coupled electron transport ( J:304562 )

• defective cellular respiration and glycolysis

decreased mitochondrial fission ( J:304562 )

• defective mitochondrial biogenesis in activated muscle stem cells

abnormal oxidative phosphorylation ( J:304562 )

• defective cellular respiration and glycolysis

muscle

impaired skeletal muscle regeneration ( J:304562 )

• virtual absence of regenerating myofibers 5 days after injection of cardiotoxin (CTX) into the tibialis anterior (TA) muscles and no muscle regeneration after 14 nor 30 days

• adipocyte infiltration 30 days after injection of cardiotoxin (CTX) into the tibialis anterior (TA) muscles