Phenotypes Associated with This Genotype

Genotype
MGI:6791353

• Allelic Composition: Bub1b^tm1Jvd/Bub1b^tm1Jvd; Mad2l1bp^tm1.1Itl/Mad2l1bp^tm1.1Itl; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:234643 )

• mice are obtained at a slightly lower than the expected number (10 versus 14.5) based on the Mendelian ratio; time of lethality is not specified

growth/size/body

decreased body weight ( J:234643 )

• mice attain ~40% of normal weight at 3 weeks of age

postnatal growth retardation ( J:234643 )

• mice appear normal at birth but fail to thrive, similar to Bub1b^tm1Jvd homozygotes

homeostasis/metabolism

hypoglycemia ( J:234643 )

• mice exhibit hypoglycemia in the fed state, similar to Bub1b^tm1Jvd homozygotes and opposite to Mad2l1bp^tm1.1Itl/Mad2l1bp^tm1.1Itl Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ mice

improved glucose tolerance ( J:234643 )

• mice exhibit increased glucose tolerance, similar to Bub1b^tm1Jvd homozygotes and opposite to Mad2l1bp^tm1.1Itl/Mad2l1bp^tm1.1Itl Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ mice

increased insulin sensitivity ( J:234643 )

• mice exhibit increased insulin sensitivity, similar to Bub1b^tm1Jvd homozygotes and opposite to Mad2l1bp^tm1.1Itl/Mad2l1bp^tm1.1Itl Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ mice

liver/biliary system

abnormal hepatocyte morphology ( J:234643 )

• at 2 months of age, the cell and nuclear sizes of hepatocytes in male mice are larger than those in single knockout mice

increased hepatocyte karyomegaly ( J:234643 )

cellular

increased hepatocyte karyomegaly ( J:234643 )

polyploidy ( J:234643 )

• mice exhibit an increased percentage of hepatocytes with 8N or greater DNA content, indicating a striking ploidy change