Phenotypes for Nbn Trp53 MGI:6780003 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nbn^em4Jpt/Nbn^em4Jpt Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbn^em4Jpt mutation (0 available); any Nbn mutation (60 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (236 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased leiomyosarcoma incidence ( J:251434 )

increased rhabdomyosarcoma incidence ( J:251434 )

increased histiocytic sarcoma incidence ( J:251434 )

increased squamous cell carcinoma incidence ( J:251434 )

increased hemangiosarcoma incidence ( J:251434 )

decreased tumor latency ( J:251434 )

• mice exhibit a reduced latency of tumor development, with a mean tumor-free survival decreased by 27-50 days relative to single Trp53 homozygous mice

muscle

increased leiomyosarcoma incidence ( J:251434 )

increased rhabdomyosarcoma incidence ( J:251434 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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