Analysis Tools
immune system
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• CD8+ T cells isolated from mutant mice show higher cytotoxic function when co-cultured with EG7 tumor cells in vitro
• congenic (CD45.1+) mice implanted with EG7 tumor cells followed by adoptive transfer of CD8+ T cells from mutant mice show smaller tumors that recipients of control T cells, indicating that antigen-specific T cells have more potent anti-tumor effector function
• recipients of mutant T cells are able to clear a Listeria monocytogenes-Ova infection more effectively than control mice
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hematopoietic system
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• CD8+ T cells isolated from mutant mice show higher cytotoxic function when co-cultured with EG7 tumor cells in vitro
• congenic (CD45.1+) mice implanted with EG7 tumor cells followed by adoptive transfer of CD8+ T cells from mutant mice show smaller tumors that recipients of control T cells, indicating that antigen-specific T cells have more potent anti-tumor effector function
• recipients of mutant T cells are able to clear a Listeria monocytogenes-Ova infection more effectively than control mice
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