Analysis Tools
immune system
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• a reduction between 30 and 50% in IgA-secreting cells in spleen and bone marrow
• a reduction between 30 and 50% in IgG-secreting cells in the bone marrow
• marker analysis shows a 50% reduction of splenic CD138/Taci+ plasmablast/plasma cell numbers; this decrease is attributed to the approximate 60% decrease in the late CD19-negative mature plasma cell subset
• the number of late CD19-negative P3-plasma cells is reduced in the bone marrow by approximately 50%, but only in the Taci+ plasma cell subset with a high abundance of surface CD138
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• 42 days after NP-KLH immunization, mice show a trend of increased numbers of NP-specific memory B cells (CD38-sIgG+) cells in the spleen and bone marrow
• numbers of pro-B cells, pre-B cells, immature B cells, and recirculating mature B cells in the bone marrow are unaltered in non-immunized mice
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• differentiation of germinal center B cells into plasmablasts is impaired resulting in a decrease in numbers of newly formed plasmablasts after immunization with NP-KLH
• however, the number of germinal center B cells is not altered
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• serum IgA levels are reduced by roughly 50% in non-immunized mice
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• serum IgG levels are reduced by roughly 50% in non-immunized mice
• mice immunized with the thymus-dependent model antigen TNP-KLH show reduced TNP-specific IgG titers
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• serum IgM levels are reduced by roughly 50% in non-immunized mice
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• mice show reduced antigen-specific antibody responses
• TNP-KLH-immunized mice show a 50% reduction in the number of TNP-specific IgG- or IgM-secreting cells in the spleen and bone marrow 70 days after primary immunization
• TNP-KLH-immunized mice show a reduction in the CD138/Taci+ plasmablast/plasma cell population in the spleen and bone marrow, indicating fewer mature P3-plasma cells
• however, the number of P1-plasmablasts and P2-plasma cells in the spleen and bone marrow are not reduced in TNP-KLH-immunized mice
• mice show lower numbers of P1-plasmablasts in the blood 14 days after primary immunization with TNP-KLH
• TNP-KLH immunized mice show a more pronounced shift to CD19+ cells in CD138/Taci+ populations under homeostatic conditions
• the number of CD138low early P2-plasma cells in the bone marrow is elevated in TNP-KLH immunized mice
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hematopoietic system
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• a reduction between 30 and 50% in IgA-secreting cells in spleen and bone marrow
• a reduction between 30 and 50% in IgG-secreting cells in the bone marrow
• marker analysis shows a 50% reduction of splenic CD138/Taci+ plasmablast/plasma cell numbers; this decrease is attributed to the approximate 60% decrease in the late CD19-negative mature plasma cell subset
• the number of late CD19-negative P3-plasma cells is reduced in the bone marrow by approximately 50%, but only in the Taci+ plasma cell subset with a high abundance of surface CD138
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• 42 days after NP-KLH immunization, mice show a trend of increased numbers of NP-specific memory B cells (CD38-sIgG+) cells in the spleen and bone marrow
• numbers of pro-B cells, pre-B cells, immature B cells, and recirculating mature B cells in the bone marrow are unaltered in non-immunized mice
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• differentiation of germinal center B cells into plasmablasts is impaired resulting in a decrease in numbers of newly formed plasmablasts after immunization with NP-KLH
• however, the number of germinal center B cells is not altered
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• serum IgA levels are reduced by roughly 50% in non-immunized mice
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• serum IgG levels are reduced by roughly 50% in non-immunized mice
• mice immunized with the thymus-dependent model antigen TNP-KLH show reduced TNP-specific IgG titers
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• serum IgM levels are reduced by roughly 50% in non-immunized mice
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