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Phenotypes Associated with This Genotype
Genotype
MGI:6724572
Allelic
Composition
Cct6bem1Jsha/Cct6bem1Jsha
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cct6bem1Jsha mutation (0 available); any Cct6b mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• teratospermia characterized by neck bending and cytoplasmic retention around the head of the neck
• curling of the flagellar tail is seen in the retained cytoplasm around the head of the sperm
• sperm exhibit decreased progressive motility
• however, males exhibit normal fertility, show normal testes and epididymis size, and normal spermatogenesis, with normal numbers of spermatocytes, round spermatids, and elongated spermatids per tubule, normal spermatogonia self-renewal, meiotic progression, and acrosome formation

cellular
• teratospermia characterized by neck bending and cytoplasmic retention around the head of the neck
• curling of the flagellar tail is seen in the retained cytoplasm around the head of the sperm
• sperm exhibit decreased progressive motility
• however, males exhibit normal fertility, show normal testes and epididymis size, and normal spermatogenesis, with normal numbers of spermatocytes, round spermatids, and elongated spermatids per tubule, normal spermatogonia self-renewal, meiotic progression, and acrosome formation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory