Phenotypes Associated with This Genotype

Genotype
MGI:6724569

• Allelic Composition: Tulp2^em1Huizh/Tulp2^em1Huizh
• Genetic Background: C57BL/6-Tulp2^em1Huizh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:307539 )

♀N • fertile and normal litter size

abnormal sperm axoneme morphology ( J:307539 )

♂ • incomplete or disorganized 2+9 microtubule arrangement

abnormal sperm midpiece morphology ( J:307539 )

♂ • incomplete peripheral dense fibers

kinked sperm flagellum ( J:307539 )

♂ • in cauda, caput and corpus epididymis

oligozoospermia ( J:307539 )

♂ • low sperm count in cauda epididymis and lumen of epididymis duct

abnormal spermatid morphology ( J:307539 )

♂ • retained elongated spermatids in middle and base of stage VII-X seminiferous tubules

increased testis apoptosis ( J:307539 )

♂ • significant increase in average number of apoptotic cells per tubule

♂ • significant increase in elongated spermatid apoptosis

decreased sperm progressive motility ( J:307539 )

♂ • low progressive motility of sperm from cauda epididymis

asthenozoospermia ( J:307539 )

♂ • low motility of sperm from cauda epididymis

male infertility ( J:307539 )

♂

endocrine/exocrine glands

increased testis apoptosis ( J:307539 )

♂ • significant increase in average number of apoptotic cells per tubule

♂ • significant increase in elongated spermatid apoptosis

cellular

abnormal sperm axoneme morphology ( J:307539 )

♂ • incomplete or disorganized 2+9 microtubule arrangement

abnormal sperm midpiece morphology ( J:307539 )

♂ • incomplete peripheral dense fibers

kinked sperm flagellum ( J:307539 )

♂ • in cauda, caput and corpus epididymis

oligozoospermia ( J:307539 )

♂ • low sperm count in cauda epididymis and lumen of epididymis duct

abnormal spermatid morphology ( J:307539 )

♂ • retained elongated spermatids in middle and base of stage VII-X seminiferous tubules

abnormal mitochondrial crista morphology ( J:307539 )

♂ • absent inner mitochondrial membrane cristae in sperm flagella

increased testis apoptosis ( J:307539 )

♂ • significant increase in average number of apoptotic cells per tubule

♂ • significant increase in elongated spermatid apoptosis

decreased sperm progressive motility ( J:307539 )

♂ • low progressive motility of sperm from cauda epididymis

asthenozoospermia ( J:307539 )

♂ • low motility of sperm from cauda epididymis