Phenotypes Associated with This Genotype

Genotype
MGI:6724441

• Allelic Composition: Prrc2a^tm1Fcw/Prrc2a^tm1Fcw; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:301796 )

nervous system

decreased astrocyte number ( J:301796 )

• slight

decreased oligodendrocyte number ( J:301796 )

abnormal astrocyte physiology ( J:301796 )

• reduced proliferation

abnormal brain morphology ( J:301796 )

• however, neuron number is normal

abnormal brain development ( J:301796 )

• impaired oligodendrocyte progenitor cell generation and proliferation with increased oligodendrocyte differentiation

decreased oligodendrocyte progenitor number ( J:301796 )

increased brain weight ( J:301796 )

enlarged lateral ventricles ( J:301796 )

abnormal corpus callosum morphology ( J:301796 )

• increased signal density on MRIs

• hypomyelination in the corpus callosum at 4 weeks of age and in adults

dysmyelination ( J:301796 )

• in the corpus callosum at 4 weeks of age and in adults

• reduced myelinated axons and myelin thickness in different brain regions

decreased nerve conduction velocity ( J:301796 )

• impaired callosal conduction velocity

growth/size/body

decreased body weight ( J:301796 )

behavior/neurological

impaired spatial learning ( J:301796 )

• learning and memory defects

impaired coordination ( J:301796 )

• on a rotarod

decreased grip strength ( J:301796 )

cellular

decreased astrocyte number ( J:301796 )

• slight

decreased oligodendrocyte number ( J:301796 )

decreased oligodendrocyte progenitor number ( J:301796 )

abnormal astrocyte physiology ( J:301796 )

• reduced proliferation