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Phenotypes Associated with This Genotype
Genotype
MGI:6723732
Allelic
Composition		 Amotl1tm1Laho/Amotl1tm1Laho
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amotl1tm1Laho mutation (0 available); any Amotl1 mutation (54 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal tumor vascularization ( J:253854 )
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit a significant increase in tumor blood vessel diameter relative to control mice
• however, tumor weight of LLC tumors is not significantly altered

neoplasm
abnormal tumor vascularization ( J:253854 )
• tamoxifen-treated mice transplanted with Lewis Lung carcinoma (LLC) cells exhibit a significant increase in tumor blood vessel diameter relative to control mice
• however, tumor weight of LLC tumors is not significantly altered

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory