Phenotypes Associated with This Genotype

Genotype
MGI:6721401

• Allelic Composition: Slc5a6^tm1.1Said/Slc5a6^tm1.1Said; Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

intestinal hemorrhage ( J:307482 )

• bloody diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout

• no diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics

diarrhea ( J:307482 )

• bloody diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout

• no diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics

abnormal intestinal epithelium morphology ( J:307482 )

• significantly increased intestinal permeability after tamoxifen-induction of intestinal epithelium-specific knockout

abnormal large intestine crypts of Lieberkuhn morphology ( J:307482 )

• cryptitis and absence of crypts in cecum after tamoxifen-induction of intestinal epithelium-specific knockout

crypts of Lieberkuhn abscesses ( J:307482 )

• in cecum after tamoxifen-induction of intestinal epithelium-specific knockout

intestinal ulcer ( J:307482 )

• mucosal erosion in cecum after tamoxifen-induction of intestinal epithelium-specific knockout

decreased colon length ( J:307482 )

• after tamoxifen-induction of intestinal epithelium-specific knockout

• virtually normal colon length after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics

abnormal intestinal epithelium physiology ( J:307482 )

• significantly increased intestinal permeability after tamoxifen-induction of intestinal epithelium-specific knockout

cecum inflammation ( J:307482 )

• severe chronic inflammation with cryptitis, crypt abscesses, and absence of crypts after tamoxifen-induction of intestinal epithelium-specific knockout

small intestinal inflammation ( J:307482 )

• acute inflammation with significant increase in neutrophil infiltration after tamoxifen-induction of intestinal epithelium-specific knockout

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:307482 )

• cryptitis and absence of crypts in cecum after tamoxifen-induction of intestinal epithelium-specific knockout

crypts of Lieberkuhn abscesses ( J:307482 )

• in cecum after tamoxifen-induction of intestinal epithelium-specific knockout

cardiovascular system

intestinal hemorrhage ( J:307482 )

• bloody diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout

• no diarrhea after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics

growth/size/body

weight loss ( J:307482 )

• progressive decline in body weight after tamoxifen-induction of intestinal epithelium-specific knockout

• virtually normal weight after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics

immune system

cecum inflammation ( J:307482 )

• severe chronic inflammation with cryptitis, crypt abscesses, and absence of crypts after tamoxifen-induction of intestinal epithelium-specific knockout

small intestinal inflammation ( J:307482 )

• acute inflammation with significant increase in neutrophil infiltration after tamoxifen-induction of intestinal epithelium-specific knockout

mortality/aging

premature death ( J:307482 )

• 50% of mice die within 8-10 days after tamoxifen-induction of intestinal epithelium-specific knockout

• normal 10-day survival after tamoxifen-induction of intestinal epithelium-specific knockout when administered broad-spectrum antibiotics