Phenotypes Associated with This Genotype

Genotype
MGI:6720821

• Allelic Composition: Crls1^tm1Geno/Crls1^tm1Geno; Tg(Ucp1-cre/ERT2)426Biat/0
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

adipose tissue phenotype ( J:266083 )

N • on a chow diet, tamoxifen-treated mice show no alterations in subcutaneous or epididymal white adipose tissue weight relative to control mice

abnormal brown adipose tissue morphology ( J:266083 )

• adult tamoxifen-treated mice exhibit a distinctly paler interscapular brown adipose tissue (iBAT) than control mice

decreased interscapular fat pad weight ( J:266083 )

• on a chow diet, tamoxifen-treated mice show a significant reduction in iBAT weight relative to control mice

homeostasis/metabolism

insulin resistance ( J:266083 )

• chow-fed mice show decreased insulin sensitivity relative to control mice

cellular

decreased mitochondrial size ( J:266083 )

• tamoxifen-treated mice exhibit reduced iBAT mitochondrial mass (as measured by citrate synthase activity)

liver/biliary system

liver/biliary system phenotype ( J:266083 )

N • on a chow diet, tamoxifen-treated mice show no alterations in liver weight relative to control mice