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Phenotypes Associated with This Genotype
Genotype
MGI:6710971
Allelic
Composition		 Gt(ROSA)26Sorem1(Tor1b)Wtd/Gt(ROSA)26Sor+
Tor1atm1Wtd/Tor1atm3.1Wtd
Tg(dlx5a-cre)1Mekk/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem1(Tor1b)Wtd mutation (1 available); any Gt(ROSA)26Sor mutation (1095 available)
Tg(dlx5a-cre)1Mekk mutation (2 available)
Tor1atm1Wtd mutation (1 available); any Tor1a mutation (22 available)
Tor1atm3.1Wtd mutation (1 available); any Tor1a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:288753 )
N
• mice show rescue of the limb clasping phenotype and the twisting movements seen in Tor1atm1Wtd/Tor1atm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice

nervous system
nervous system phenotype ( J:288753 )
N
• mice show prevention of striatal cholinergic interneuron degeneration that occurs in Tor1atm1Wtd/Tor1atm3.1Wtd Tg(Dlx5a-cre)1Mekk/0 mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory