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Phenotypes Associated with This Genotype
Genotype
MGI:6710964
Allelic
Composition		 Gt(ROSA)26Sorem1(Tor1b)Wtd/Gt(ROSA)26Sor+
Tor1atm2Wtd/Tor1atm3.1Wtd
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sorem1(Tor1b)Wtd mutation (1 available); any Gt(ROSA)26Sor mutation (1095 available)
Tg(Nes-cre)1Kln mutation (4 available)
Tor1atm2Wtd mutation (1 available); any Tor1a mutation (22 available)
Tor1atm3.1Wtd mutation (1 available); any Tor1a mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:288753 )
N
• mice show almost complete rescue of the abnormal postural (squinty eyes and twisted hindpaws) and development phenotypes seen in Tor1atm2Wtd/Tor1atm3.1Wtd Tg(Nes-cre)1Kln/0 mice

growth/size/body
growth/size/body region phenotype ( J:288753 )
N
• mice exhibit partial rescue of the postnatal growth retardation seen in Tor1atm2Wtd/Tor1atm3.1Wtd Tg(Nes-cre)1Kln/0 mice from P8 to P28 and are fully restored to normal weight by P56

nervous system
nervous system phenotype ( J:288753 )
N
• mice do not exhibit neurodegeneration or gliosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory