Phenotypes for Myh3 Pax7 MGI:6695908 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Myh3^tm1.2Sajm/Myh3^tm1.1Sajm Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh3^tm1.1Sajm mutation (0 available); any Myh3 mutation (74 available)
Myh3^tm1.2Sajm mutation (0 available); any Myh3 mutation (74 available)
Pax7^tm1(cre)Mrc mutation (2 available); any Pax7 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell morphology ( J:287755 )

• reduction in myogenic precursor marker Pax7 peptide level and 50% reduction in Pax7+ myogenic precursor cells in E16.5 embryos

• significantly reduced levels of committed myoblast markers MyoD and myogenin peptide levels and 60% reduction in MyoD+ myoblasts in E16.5 embryos

• 7x increased MyHC-slow peptide levels in E16.5 embryos

cellular

cellular phenotype ( J:287755 )

N	• normal apoptosis in E16.5 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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