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Phenotypes Associated with This Genotype
Genotype
MGI:6694954
Allelic
Composition		 Eaf1tm1.1Zhow/Eaf1tm1.1Zhow
Eaf2tm1Zhow/Eaf2tm1Zhow
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eaf1tm1.1Zhow mutation (0 available); any Eaf1 mutation (15 available)
Eaf2tm1Zhow mutation (0 available); any Eaf2 mutation (19 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased prostate intraepithelial neoplasia incidence ( J:288972 )
• mouse prostatic intraepithelial neoplasia (mPIN) lesions
abnormal prostate gland physiology ( J:288972 )
• increased epithelial cell proliferation in ventral prostate
prostate gland inflammation ( J:288972 )
• stroma inflammation
• increased CD3+ T cell and CD19+ B cell infiltration of ventral prostate

immune system
prostate gland inflammation ( J:288972 )
• stroma inflammation
• increased CD3+ T cell and CD19+ B cell infiltration of ventral prostate

neoplasm
increased prostate intraepithelial neoplasia incidence ( J:288972 )
• mouse prostatic intraepithelial neoplasia (mPIN) lesions

reproductive system
increased prostate intraepithelial neoplasia incidence ( J:288972 )
• mouse prostatic intraepithelial neoplasia (mPIN) lesions
abnormal prostate gland physiology ( J:288972 )
• increased epithelial cell proliferation in ventral prostate
prostate gland inflammation ( J:288972 )
• stroma inflammation
• increased CD3+ T cell and CD19+ B cell infiltration of ventral prostate

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory