Phenotypes Associated with This Genotype

Genotype
MGI:6693797

• Allelic Composition: \Del(8Ddx19a-Ddx19b)1Chaw/\+
• Genetic Background: C57BL/6-Del(8Ddx19a-Ddx19b)1Chaw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased interferon-alpha secretion ( J:289833 )

• by macrophages incubated with poly(I:C) or infected with Sendai virus (SeV)

increased interferon-beta secretion ( J:289833 )

• by macrophages incubated with poly(I:C) or infected with Sendai virus (SeV)

decreased susceptibility to Picornaviridae infection ( J:289833 )

• fewer copies of virus genome in mouse embryo fibroblasts (MEFs) infected with Encephalomyocarditis virus (EMCV)

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:289833 )

• significantly less pronounced damage to brain and heart after Encephalomyocarditis virus (EMCV) infection

• lower viral load in brain and heart after Encephalomyocarditis virus (EMCV) infection

growth/size/body

growth/size/body region phenotype ( J:289833 )

N • no gross abnormalities

mortality/aging

mortality/aging ( J:289833 )

N • viable

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:289833 )

• significantly less pronounced damage to brain and heart after Encephalomyocarditis virus (EMCV) infection

• lower viral load in brain and heart after Encephalomyocarditis virus (EMCV) infection

reproductive system

reproductive system phenotype ( J:289833 )

N • fertile