Phenotypes Associated with This Genotype

Genotype
MGI:6690684

• Allelic Composition: Gck^tm1Ydor/Gck⁺; Tg(Ins1-cre/ERT)1Lphi/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

hypoglycemia ( J:302600 )

• mice treated with tamoxifen exhibit long-term, persistent hypoglycemia

impaired glucose tolerance ( J:302600 )

• 9-month-old tamoxifen-treated mice, but not 1.5-month-old tamoxifen-treated mice, exhibit abnormal glucose tolerance

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:302600 )

• tamoxifen-treated mice exhibit an increase in beta cell mass at 1.5 months of age, but this increase is no longer seen at 9 months of age