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Phenotypes Associated with This Genotype
Genotype
MGI:6690656
Allelic
Composition		 Gm16685em1Osb/Gm16685em1Osb
Genetic
Background		 C57BL/6N-Gm16685em1Osb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gm16685em1Osb mutation (0 available); any Gm16685 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased susceptibility to colitis induced morbidity/mortality ( J:303079 )
• less severe weight loss and less pronounced colon shortening after dextran sulphate sodium (DSS) administration
• reduced levels of CD11b+ Ly6c-hi Ly6g and increased levels of CD11b+ Ly6c-low Ly6g+ myeloid cells in bone marrow after DSS administration

hematopoietic system
hematopoietic system phenotype ( J:303079 )
N
• normal hematopoietic stem cell and progenitor cell populations in bone marrow

immune system
decreased susceptibility to colitis induced morbidity/mortality ( J:303079 )
• less severe weight loss and less pronounced colon shortening after dextran sulphate sodium (DSS) administration
• reduced levels of CD11b+ Ly6c-hi Ly6g and increased levels of CD11b+ Ly6c-low Ly6g+ myeloid cells in bone marrow after DSS administration

mortality/aging
decreased susceptibility to colitis induced morbidity/mortality ( J:303079 )
• less severe weight loss and less pronounced colon shortening after dextran sulphate sodium (DSS) administration
• reduced levels of CD11b+ Ly6c-hi Ly6g and increased levels of CD11b+ Ly6c-low Ly6g+ myeloid cells in bone marrow after DSS administration

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory