Phenotypes Associated with This Genotype

Genotype
MGI:6682105

• Allelic Composition: Pex16^{tm1c(EUCOMM)Hmgu}/Pex16^{tm1c(EUCOMM)Hmgu}; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: C57BL/6N * FVB/NJ * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:270463 )

• in cold exposed mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:270463 )

N • mice fed a high-fat diet exhibit normal resting energy metabolism

increased susceptibility to diet-induced obesity ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

• cold exposed mice exhibit whitening of brown adipose tissue and increased lethality unlike control mice

• however, diet-induced obesity is normal at 30 degrees Celcius

impaired adaptive thermogenesis ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

• however, diet-induced obesity is normal at 30 degrees Celcius and thermogenesis is recused by a diet containing alkylglycerols

decreased oxygen consumption ( J:270463 )

• reduced oxygen consumption after treatment with norepinephrine

impaired glucose tolerance ( J:270463 )

• in mice fed standard chow

• however, no difference is observed when mice are fed a high-fat diet

abnormal response/metabolism to endogenous compounds ( J:270463 )

• reduced oxygen consumption after treatment with norepinephrine

adipose tissue

increased total body fat amount ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

increased brown fat cell lipid droplet size ( J:270463 )

• in cold exposed mice

whitened brown adipose tissue morphology ( J:270463 )

• after cold treatment, brown adipose tissue is paler with higher levels of triglyceride content compared with control mice

• however, mitochondria cristae are normal

decreased fat cell mitochondrial DNA content ( J:270463 )

• in brown adipose tissue at 22 and 4 degrees Celsius

• in white adipose tissue at 4 degrees Celsius

• however, mitochondrial DNA content is recused by a diet containing alkylglycerols

increased white fat cell size ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

increased gonadal fat pad weight ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

growth/size/body

increased susceptibility to diet-induced obesity ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

• cold exposed mice exhibit whitening of brown adipose tissue and increased lethality unlike control mice

• however, diet-induced obesity is normal at 30 degrees Celcius

behavior/neurological

behavior/neurological phenotype ( J:270463 )

N • mice fed a high-fat diet exhibit normal food intake and physical activity

cellular

decreased fat cell mitochondrial DNA content ( J:270463 )

• in brown adipose tissue at 22 and 4 degrees Celsius

• in white adipose tissue at 4 degrees Celsius

• however, mitochondrial DNA content is recused by a diet containing alkylglycerols

abnormal mitochondrial physiology ( J:270463 )

• impaired mitochondrial fatty acid oxidation and modest reduction in citrate synthase activity

• however, mitochondrial function is improved by a diet containing alkylglycerols