Phenotypes Associated with This Genotype

Genotype
MGI:6681839

• Allelic Composition: \Myo9a^em1Atuf/\Myo9a^em1Atuf
• Genetic Background: C57BL/6J-Myo9a^em1Atuf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:302901 )

• almost all mice die before 3 weeks of age

behavior/neurological

ataxia ( J:302901 )

• mice develop ataxia

seizures ( J:302901 )

• mice develop seizures

homeostasis/metabolism

increased urine protein level ( J:302901 )

• all mice develop proteinuria

albuminuria ( J:302901 )

• albuminuria is seen at 2 weeks of age

nervous system

seizures ( J:302901 )

• mice develop seizures

hydrocephaly ( J:302901 )

• mice develop progressive hydrocephalus

renal/urinary system

increased urine protein level ( J:302901 )

• all mice develop proteinuria

albuminuria ( J:302901 )

• albuminuria is seen at 2 weeks of age

podocyte foot process effacement ( J:302901 )

• all mice develop foot process effacement

absent podocyte slit diaphragm ( J:302901 )

• kidneys of 2-week-oold mice lack slit diaphragms replaced by adherens junctions

abnormal renal glomerulus basement membrane morphology ( J:302901 )

• kidneys show irregular glomerular basement membrane at 2 weeks of age

increased renal glomerulus basement membrane thickness ( J:302901 )

• kidneys show thick glomerular basement membrane at 2 weeks of age

abnormal renal glomerulus morphology ( J:302901 )

• mice show dysmorphic glomeruli at 2 weeks of age

dilated renal tubule ( J:302901 )

• mice show tubular dilatation at 2 weeks of age

dilated nephron ( J:302901 )

• distal nephron dilatation is seen at 2 weeks of age