Phenotypes Associated with This Genotype

Genotype
MGI:6515792

• Allelic Composition: Sppl3^tm1Itl/Sppl3^em1Pomz; Ncr1^{tm1.1(icre)Viv}/Ncr1⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:280182 )

N • mice are born in Mendelian ratios and survive without any overt phenotype

immune system

abnormal NK cell differentiation ( J:280182 )

• mice show a defect in NK cell maturation with a 1.8-fold reduction of CD27+CD11b+ NK cells in the bone marrow and a 3-fold loss of CD27+CD11b+ NK cells in spleen

increased immature NK cell number ( J:280182 )

• mice show a 1.4-fold increase in the number of immature CD27+CD11b- NK cells in bone marrow but no significant change in spleen

decreased NK cell number ( J:280182 )

• mice exhibit reduced numbers of peripheral NK cells with a 2.9-fold reduction of NK cell number in spleen

• however, NK cell number is normal in the bone marrow

decreased mature NK cell number ( J:280182 )

• mice show a 6-fold reduction of mature CD27-CD11b+ NK cells in spleen, and 3-fold loss of CD27-CD11b+ NK cells in the bone marrow

hematopoietic system

abnormal NK cell differentiation ( J:280182 )

• mice show a defect in NK cell maturation with a 1.8-fold reduction of CD27+CD11b+ NK cells in the bone marrow and a 3-fold loss of CD27+CD11b+ NK cells in spleen

increased immature NK cell number ( J:280182 )

• mice show a 1.4-fold increase in the number of immature CD27+CD11b- NK cells in bone marrow but no significant change in spleen

decreased NK cell number ( J:280182 )

• mice exhibit reduced numbers of peripheral NK cells with a 2.9-fold reduction of NK cell number in spleen

• however, NK cell number is normal in the bone marrow

decreased mature NK cell number ( J:280182 )

• mice show a 6-fold reduction of mature CD27-CD11b+ NK cells in spleen, and 3-fold loss of CD27-CD11b+ NK cells in the bone marrow