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Phenotypes Associated with This Genotype
Genotype
MGI:6514876
Allelic
Composition
Ace2em2(ACE2)Gpt/Y
Genetic
Background
C57BL/6JGpt-Ace2em2(ACE2)Gpt/Gpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2em2(ACE2)Gpt mutation (0 available); any Ace2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice infected with SARS-CoV-2 exhibit severe lung lesions as shown by infiltration of inflammatory cells and thickened alveolar septa
• mice are susceptible to infection with SARS-CoV-2 , showing viral RNA in the lungs and severe lung lesions, infiltration of inflammatory cells, and thickened alveolar septa
• treatment with Nb(15)-Nb(H)-Nb(15), a heterotrimer of neutralizing nanobodies derived from an alpaca immunized with SARS-CoV-2 spike glycoprotein constructed to be bispecific for human serum albumin and RBD of SARS-CoV-2, 24 hours before or 1 hour after SARS-CoV-2 viral challenge provides complete protection against infection and significantly inhibits viral replication when administered 24 hours post infection

respiratory system
• mice infected with SARS-CoV-2 exhibit severe lung lesions as shown by infiltration of inflammatory cells and thickened alveolar septa

growth/size/body
• mice infected with SARS-CoV-2 show weight loss


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory