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Phenotypes Associated with This Genotype
Genotype
MGI:6514750
Allelic
Composition		 Chmp1aGt(XC472)Byg/Chmp1aGt(XC472)Byg
Ptch1tm1Mps/Ptch1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chmp1aGt(XC472)Byg mutation (1 available); any Chmp1a mutation (14 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:271138 )
N
• at E18.5/P0, brain weight is not significantly different from that in controls, indicating that the microcephaly of Chmp1aGt(XC472)Byg homozygotes (reflecting reduced Shh function) is reversed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory