Phenotypes Associated with This Genotype

Genotype
MGI:6510869

• Allelic Composition: Gpr82^tm1Shbg/Y
• Genetic Background: C3Fe.Cg-Gpr82^tm1Shbg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal adipose tissue amount ( J:301613 )

♂ • reduction in visceral fat mass

♂ • fat tissue from Western diet-fed mice shows a diet-induced increase in the fat-to-water ratio; this is not seen on the standard diet

decreased total body fat amount ( J:301613 )

♂ • lower absolute and relative body fat content

decreased fat cell size ( J:301613 )

♂ • average size of adipocytes in perigonadal fat pads is lower

behavior/neurological

decreased food intake ( J:301613 )

♂ • food intake is reduced during the light and dark phase

abnormal locomotor circadian rhythm ( J:301613 )

♂ • mice show a reduced motor activity during the dark period but not during the light phase

decreased locomotor activity ( J:301613 )

♂ • mice show reduced locomotion in the open field

increased thermal nociceptive threshold ( J:301613 )

♂ • mice show increased heat tolerance on the hot plate test

growth/size/body

increased lean body mass ( J:301613 )

♂ • lean mass relative to the body weight is increased

decreased body weight ( J:301613 )

♂

decreased susceptibility to weight gain ( J:301613 )

♂ • males fed a Western diet gain less weight than wild-type mice fed a Western diet

homeostasis/metabolism

decreased circulating glucose level ( J:301613 )

♂ • males fed a Western diet show lower basal glucose levels compared to wild-type mice

decreased fasting circulating glucose level ( J:301613 )

♂ • males show lower fasting blood glucose levels

decreased circulating insulin level ( J:301613 )

♂ • fasting serum insulin levels are only slightly lower

decreased circulating VLDL cholesterol level ( J:301613 )

♂ • cholesterol is reduced only in the VLDL fraction

increased body temperature ( J:301613 )

♂ • mice show a small, but significant, increase in body temperature

♂ • however, no differences in the respiratory and metabolic rates are seen

improved glucose tolerance ( J:301613 )

♂ • mice show improved glucose tolerance in oral glucose tolerance tests

♂ • Western diet-fed mice show improved glucose tolerance following intraperitoneal glucose application

decreased triglyceride level ( J:301613 )

♂ • lower triacylglyceride levels; triacylglyceride levels are lower in all three lipoprotein fractions (LDL, HDL, VLDL)