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Phenotypes Associated with This Genotype
Genotype
MGI:6509155
Allelic
Composition		 Del(13Naip1-Naip5)1Vnce/Del(13Naip1-Naip5)1Vnce
Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13Naip1-Naip5)1Vnce mutation (2 available); any Del(13Naip1-Naip5)1Vnce mutation (1 available)
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased lactate dehydrogenase level ( J:294930 )
• severe reduction in LDH released by bone marrow derived macrophages exposed to Salmonella Typhimurium

immune system
decreased inflammatory response ( J:294930 )
• severe reduction in inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory