About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6509152
Allelic
Composition		 \Nlrc4em2Vnce/\Nlrc4em2Vnce
\Nlrp3tm1Vmd/\Nlrp3tm1Vmd
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4em2Vnce mutation (1 available); any Nlrc4 mutation (67 available)
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased lactate dehydrogenase level ( J:294930 )
• 40-50% reduction in LDH released by bone marrow derived macrophages (BMDMs) exposed to low doses of cytosolic Legionella pneumophila flagellin whether primed with LPS or not

immune system
decreased inflammatory response ( J:294930 )
• significantly reduced inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin whether primed with LPS or not
• severely reduced inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory