Phenotypes Associated with This Genotype

Genotype
MGI:6508101

• Allelic Composition: Fancm^em1Qsh/Fancm^em1Qsh
• Genetic Background: C57BL/6-Fancm^em1Qsh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatid morphology ( J:301639 )

♂ • round spermatids as most developed stage in 43.5% of tubules

increased male germ cell apoptosis ( J:301639 )

♂ • in adult mice

♂ • age-related progressive reduction in spermatogonial stem cell to Sertoli cell ratio

♂ • increased sensitivity of spermatogonia to mitomycin C

abnormal seminiferous tubule morphology ( J:301639 )

♂ • 7.6% of tubules Sertoli cell only (SCO)

♂ • loss of germ cells of multiple stages in 42.6% of tubules

♂ • round spermatids as most developed stage in 43.5% of tubules

♂ • large proportion of atypical stage IIVI tubules lacking elongating/ed spermatids in adult testes

♂ • reduced stage VII-XII tubule frequency

seminiferous tubule degeneration ( J:301639 )

♂ • in adult mice

male infertility ( J:301639 )

♂

cellular

abnormal spermatid morphology ( J:301639 )

♂ • round spermatids as most developed stage in 43.5% of tubules

increased cellular sensitivity to DNA damaging agent induced cell death ( J:301639 )

♂ • increased sensitivity of spermatogonia to mitomycin C

increased male germ cell apoptosis ( J:301639 )

♂ • in adult mice

♂ • age-related progressive reduction in spermatogonial stem cell to Sertoli cell ratio

♂ • increased sensitivity of spermatogonia to mitomycin C

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:301639 )

♂ • 7.6% of tubules Sertoli cell only (SCO)

♂ • loss of germ cells of multiple stages in 42.6% of tubules

♂ • round spermatids as most developed stage in 43.5% of tubules

♂ • large proportion of atypical stage IIVI tubules lacking elongating/ed spermatids in adult testes

♂ • reduced stage VII-XII tubule frequency

seminiferous tubule degeneration ( J:301639 )

♂ • in adult mice

neoplasm

neoplasm ( J:301639 )

♂N • no cancer incidence in 1st year

hematopoietic system

hematopoietic system phenotype ( J:301639 )

♂N • normal blood cell count, hemoglobin levels and other hematological parameters