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Phenotypes Associated with This Genotype
Genotype
MGI:6507152
Allelic
Composition
Tuba1aem2Rstot/Tuba1aem2Rstot
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tuba1aem2Rstot mutation (0 available); any Tuba1a mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are present at E18.5 but all are lost by weaning

nervous system
• 50% reduction in size at E16.5
• 30% reduction in the width at E16.5
• widened base in posterior brain regions
• reduced basal ganglia

homeostasis/metabolism
• thoracic edema

cardiovascular system
• hemorrhage in the cervical region extending towards the forelimbs

craniofacial
• in 3 of 11 embryos

skeleton
• thoracic curvature

growth/size/body
• in 3 of 11 embryos

digestive/alimentary system
• in 3 of 11 embryos

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital nervous system abnormality DOID:2490 J:278765


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory