Phenotypes Associated with This Genotype

Genotype
MGI:6506382

• Allelic Composition: Stag3^{tm1e.1(KOMP)Wtsi}/Stag3^{tm1e.1(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Stag3^{tm1e.1(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal chromosomal synapsis ( J:280261 )

♂ • aberrant homolog pairing with increased incidence of chromosomes occupying more than one territoriy in spermatocytes

abnormal male meiosis ( J:280261 )

♂ • defective sister-chromatid cohesion in spermatocytes

♂ • aberrant chromatin compaction with chromosomes occupying larger and more than one territories in spermatocytes

♂ • reduced number (50% of WT) of recombination hotspots in leptotene-like spermatocytes

♂ • increased representation of pre-leptonema to zygonema-like stage spermatocytes in testis

abnormal synaptonemal complex ( J:280261 )

♂ • absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

increased male germ cell apoptosis ( J:280261 )

♂

cellular

abnormal chromosomal synapsis ( J:280261 )

♂ • aberrant homolog pairing with increased incidence of chromosomes occupying more than one territoriy in spermatocytes

abnormal male meiosis ( J:280261 )

♂ • defective sister-chromatid cohesion in spermatocytes

♂ • aberrant chromatin compaction with chromosomes occupying larger and more than one territories in spermatocytes

♂ • reduced number (50% of WT) of recombination hotspots in leptotene-like spermatocytes

♂ • increased representation of pre-leptonema to zygonema-like stage spermatocytes in testis

abnormal synaptonemal complex ( J:280261 )

♂ • absence of linear SC, forming instead a more punctuate SC around centromeres in spermatocytes

increased male germ cell apoptosis ( J:280261 )

♂

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (66% of WT) in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:280261 )

♂ • reduced number of double-strand DNA breaks (66% of WT) in spermatocytes