Phenotypes Associated with This Genotype

Genotype
MGI:6502846

• Allelic Composition: Gpr35^em2Niess/Gpr35^em2Niess; Cx3cr1^{tm2.1(cre/ERT2)Litt}/Cx3cr1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

decreased colon length ( J:300275 )

• in mice treated with tamoxifen and DSS

• however, treatment with TNF attenuates exacerbated DSS-induced colon reduction

increased susceptibility to induced colitis ( J:300275 )

• in mice treated with tamoxifen and DSS with increased body weight loss, disease activity scores, and enteroscopic and histological colitis scores, and reduced colon length that are not responsive to LPA treatment

• increased inflammation is not associated with higher macrophage infiltration into the colonic lamina prioria in mice treated with tamoxifen and DSS

• however, treatment with TNF attenuates exacerbated DSS-induced colitis

growth/size/body

increased susceptibility to weight loss ( J:300275 )

• in mice treated with tamoxifen and DSS

• however, treatment with TNF attenuates exacerbated DSS-induced weight loss

immune system

increased susceptibility to induced colitis ( J:300275 )

• in mice treated with tamoxifen and DSS with increased body weight loss, disease activity scores, and enteroscopic and histological colitis scores, and reduced colon length that are not responsive to LPA treatment

• increased inflammation is not associated with higher macrophage infiltration into the colonic lamina prioria in mice treated with tamoxifen and DSS

• however, treatment with TNF attenuates exacerbated DSS-induced colitis

homeostasis/metabolism

abnormal corticosterone level ( J:300275 )

• lower corticosterone concentrations from the supernatants of colonic explants of mice treated with tamoxifen and DSS

• however, treatment with TNF increases corticosterone concentrations from the supernatants of colonic explants of mice treated with tamoxifen and DSS