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Phenotypes Associated with This Genotype
Genotype
MGI:6501995
Allelic
Composition
Ifnar1tm1Agt/Ifnar1tm1Agt
Tg(CD46)373Zbz/Tg(CD46)373Zbz
Genetic
Background
involves: 129S2/SvPas * C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar1tm1Agt mutation (11 available); any Ifnar1 mutation (41 available)
Tg(CD46)373Zbz mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice inoculated intracerebrally with the attenuated Edmonston measles virus (MV-Edm) show increased lethality after two days post infection
• 50% of mice inoculated with the rat brain-adapted neurotrophic measles virus strain CAM/RBH succumb 5-11 days post infection

immune system
• mice infected intracerebrally with MV-Edm show encephalitis
• mice infected intracerebrally with MV-Edm exhibit meningitis with inflammatory infiltrates of leukocytes and extensive vacuolization and necrosis of nearby brain parenchyma
• mice inoculated intranasally with MV-Edm show acute lung inflammation
• mice inoculated intranasally with the attenuated Edmonston measles virus (MV-Edm) show larger purple lesions in the lungs than seen in Ifnar1tm1Agt homozygotes
• mice inoculated intranasally with MV-Edm show acute lung inflammation, extensive hyperemia, and diffuse hemorrhage in large areas of the lungs and show peak virus levels in the lungs at day 6 post infection which spreads to liver, spleen, kidney, and peripheral blood mononuclear cells
• susceptibility to MV-Edm infection is more pronounced if less virus is inoculated
• mice inoculated intracerebrally with MV-Edm show increased lethality after two days post infection and show clinical signs of neural disease, including initial hyperactivity followed by awkward gait, lethargy, lack of mobility, and death
• mice inoculated intracerebrally with the attenuated Edmonston measles virus (MV-Edm) show increased lethality after two days post infection
• 50% of mice inoculated with the rat brain-adapted neurotrophic measles virus strain CAM/RBH succumb 5-11 days post infection

respiratory system
• mice inoculated intranasally with MV-Edm show diffuse hemorrhage in large areas of the lungs
• mice inoculated intranasally with MV-Edm show extensive hyperemia
• mice inoculated intranasally with MV-Edm show acute lung inflammation

nervous system
• mice infected intracerebrally with MV-Edm show encephalitis
• mice infected intracerebrally with MV-Edm exhibit meningitis with inflammatory infiltrates of leukocytes and extensive vacuolization and necrosis of nearby brain parenchyma
• mice infected intracerebrally with MV-Edm show numerous reactive astrocytes in many brain areas
• mice infected intracerebrally with MV-Edm exhibit necrosis of neurons in the cerebral cortex, corpus callosum, and hypothalamus

behavior/neurological
• mice inoculated intracerebrally with MV-Edm show initial hyperactivity that is followed by awkward gait and lethargy
• mice inoculated intracerebrally with MV-Edm show initial hyperactivity followed by awkward gait and lack of mobility
• mice inoculated intracerebrally with MV-Edm show initial hyperactivity following infection

cardiovascular system
• mice inoculated intranasally with MV-Edm show diffuse hemorrhage in large areas of the lungs
• mice inoculated intranasally with MV-Edm show extensive hyperemia

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
measles DOID:8622 J:160878


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory