Phenotypes Associated with This Genotype

Genotype
MGI:6493200

• Allelic Composition: Ykt6^em1(IMPC)J/Ykt6^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Ykt6^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Ykt6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ykt6^em1(IMPC)J/Ykt6^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida and are dead after 72hr in vitro outgrowth culture.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that blastocysts fail to hatch from the zona pellucida and are dead after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• although early blastocysts are present in expected Mendelian ratios at E3.5, no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo