Ykt6^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ykt6^em1(IMPC)J
• Name: YKT6 v-SNARE homolog (S. cerevisiae); endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6360693
• Synonyms: Ykt6^-
• Gene: Ykt6 Location: Chr11:5905779-5917780 bp, + strand Genetic Position: Chr11, 3.89 cM
• Alliance: Ykt6^em1(IMPC)J page
• IMPC: Ykt6 gene page

Ykt6^em1(IMPC)J/Ykt6^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida and are dead after 72hr in vitro outgrowth culture.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory using Cas9 and guides with spacer sequences TCACACTGTCCCCAACACAG and TGGATAGGAGAAGCAAGGCG that targeted exon(s) ENSMUSE00000105087.2. This resulted in deletion(s) of 248 bp (location: Chr11:5909240-5909487; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ykt6 Mutation: 16 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 5 reference(s)