Phenotypes Associated with This Genotype

Genotype
MGI:6493078

• Allelic Composition: Scfd1^em1(IMPC)Tcp/Scfd1^em1(IMPC)Tcp
• Genetic Background: C57BL/6N-Scfd1^em1(IMPC)Tcp/Cmmr

Data Sources

IMPC Data for Scfd1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Scfd1^em1(IMPC)Tcp/Scfd1^em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. In vitro, some blastocysts fail to hatch from the zona pellucida and do not form outgrowths while others do hatch but form outgrowths with no inner cell mass and dispersed trophectoderm.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that some blastocysts fail to hatch from the zona pellucida after 3 days in culture

absent inner cell mass ( J:279207 )

• in vitro, some blastocysts do hatch from the zona but form outgrowths with no apparent inner cell mass (ICM) after 3 days in culture

abnormal trophectoderm morphology ( J:279207 )

• in vitro, blastocysts that do hatch form outgrowths with no apparent ICM and dispersed trophectoderm (TE) after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• although blastocyst-like embryos are present in expected Mendelian ratios at E3.5, no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

failure of embryo implantation ( J:279207 )

• in vitro, some blastocysts fail to hatch and do not form outgrowths after 3 days in culture