Phenotypes Associated with This Genotype

Genotype
MGI:6492948

• Allelic Composition: Mbip^em1(IMPC)J/Mbip^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Mbip^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Mbip

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mbip^em1(IMPC)J/Mbip^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Blastocysts grown in vitro hatch from the zona pellucida but form irregular outgrowths.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• blastocysts are recovered at E3.5 (12% versus expected 25%, n=43); no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

abnormal embryo implantation ( J:279207 )

• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture