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Phenotypes Associated with This Genotype
Genotype
MGI:6491890
Allelic
Composition
Coasytm1.1Vtr/Coasytm1.1Vtr
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: 129 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coasytm1.1Vtr mutation (0 available); any Coasy mutation (8 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• dystonia-like movements with flexing or prolonged stiff extension of the limbs and tail rigidity
• tail rigidity

cellular
• impairment of pyruvate-dependent mitochondrial respiration in the brain

growth/size/body
• starting at P8
• starting at P8

homeostasis/metabolism
• increased in the brain
• increased in the brain

mortality/aging
• mice were euthanized around P13 for compassionate reasons

muscle
• dystonia-like movements with flexing or prolonged stiff extension of the limbs and tail rigidity

nervous system
N
• forebrains exhibit normal troughs and no astrocytosis, neuroinflammation, neuronal loss or intracellular inclusion

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
neurodegeneration with brain iron accumulation 6 DOID:0110740 OMIM:615643
J:299154


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory