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Phenotypes Associated with This Genotype
Genotype
MGI:6488227
Allelic
Composition
Btbd9tm1c(EUCOMM)Wtsi/Btbd9tm1c(EUCOMM)Wtsi
Tg(Pcp2-cre)2Mpin/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btbd9tm1c(EUCOMM)Wtsi mutation (0 available); any Btbd9 mutation (40 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit an increase in voluntary activity level in the wheel-running test during the light phase, but no change during the dark phase; activity is especially high at 9 am and especially low during the 1st half of the active phase
• mice exhibit an increase in activity level during the rest (light) phase and during the active (dark) phase in the continuous open field
• however, mice show no difference in the latency to withdraw from the heat stimuli in the tail-flick test
• analysis of sleep-like behaviors indicates an increase in probability of waking in the rest phase, especially at 7 am, 8 am and the 2nd half of the rest phase, but not in the active phase

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
restless legs syndrome DOID:0050425 OMIM:PS102300
J:298663


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory