Phenotypes Associated with This Genotype

Genotype
MGI:6479634

• Allelic Composition: Cdk8^{tm1a(EUCOMM)Hmgu}/Cdk8^{tm1a(EUCOMM)Hmgu}; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased insulin secretion ( J:281075 )

• plasma insulin levels are increased at 2 min and 5 min of glucose challenge, but not at later 15 and 30 min time point

• however, insulin sensitivity and insulin content remain unchanged

homeostasis/metabolism

increased insulin secretion ( J:281075 )

• plasma insulin levels are increased at 2 min and 5 min of glucose challenge, but not at later 15 and 30 min time point

• however, insulin sensitivity and insulin content remain unchanged

improved glucose tolerance ( J:281075 )

• mice fed a normal diet show augmented glucose tolerance