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Phenotypes Associated with This Genotype
Genotype
MGI:6478838
Allelic
Composition
Amigo2em#Dke/Amigo2em#Dke
Genetic
Background
involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amigo2em#Dke mutation (0 available); any Amigo2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased dendrite size and larger occupied territory of mid-eccentricity ON and OFF SACs
• normal dendrite arbor branch distribution relative to dendrite size of mid-eccentricity ON and OFF SACs
• normal density of mid-eccentricity ON SACs and their distribution in ganglion cell layer as measured by density recovery profiles
• normal density of mid-eccentricity OFF SACs and their distribution in inner nuclear layer
• normal stratification of mid-eccentricity SAC dendrites in inner plexiform layer (IPL)
• increased dendrite size and larger occupied territory mid-eccentricity RBCs
• normal density in inner nuclear layer of mid-eccentricity RBCs
• normal stratification of mid-eccentricity RBC axons in inner plexiform layer (IPL)
• normal input synapse distribution on mid-eccentricity RBC dendrites relative to dendrite size
• normal axon territory size
• enhanced direction selectivity of DSGC responses to starburst amacrine cell signals

vision/eye
N
• normal retina surface area
• normal stratification of starburst amacrine cell (SAC) and retinal rod bipolar cell (RBC) neurites in inner plexiform layer (IPL)
• normal horizontal cell axon and dendrite size
• increased dendrite size and larger occupied territory of mid-eccentricity ON and OFF SACs
• normal dendrite arbor branch distribution relative to dendrite size of mid-eccentricity ON and OFF SACs
• normal density of mid-eccentricity ON SACs and their distribution in ganglion cell layer as measured by density recovery profiles
• normal density of mid-eccentricity OFF SACs and their distribution in inner nuclear layer
• normal stratification of mid-eccentricity SAC dendrites in inner plexiform layer (IPL)
• increased dendrite size and larger occupied territory mid-eccentricity RBCs
• normal density in inner nuclear layer of mid-eccentricity RBCs
• normal stratification of mid-eccentricity RBC axons in inner plexiform layer (IPL)
• normal input synapse distribution on mid-eccentricity RBC dendrites relative to dendrite size
• normal axon territory size
• enhanced direction selectivity of DSGC responses to starburst amacrine cell signals


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/31/2026
MGI 6.24
The Jackson Laboratory