Phenotypes Associated with This Genotype

Genotype
MGI:6477408

• Allelic Composition: Trp63^tm2.1Aam/Trp63^tm3.1Aam
• Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

cleft palate ( J:294158 )

• 70% of neonates exhibit cleft palate

digestive/alimentary system

cleft palate ( J:294158 )

• 70% of neonates exhibit cleft palate

growth/size/body

cleft palate ( J:294158 )

• 70% of neonates exhibit cleft palate

integument

thick dermal layer ( J:294158 )

• dermis is thicker in large areas of the skin

abnormal epidermal layer morphology ( J:294158 )

• epidermis is abnormal with the stratum basale and stratum spinosum affected

thick epidermis stratum basale ( J:294158 )

thick epidermis stratum spinosum ( J:294158 )

thick epidermis ( J:294158 )

• thickening of Trp63-, K14-, and K10-expressing layers in patches of the epidermis covering the skin surface

limbs/digits/tail

limbs/digits/tail phenotype ( J:294158 )

N • neonates do not exhibit limb defects