Phenotypes for Trp63 MGI:6477394 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Trp63^tm3Aam/Trp63^tm3Aam
Genetic Background	involves: 129S7/SvEvBrd

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63^tm3Aam mutation (0 available); any Trp63 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryo

abnormal embryo development ( J:294158 )

• defects in epithelial morphogenesis

integument

abnormal skin development ( J:294158 )

• neonates lack a mature skin barrier

limbs/digits/tail

abnormal limb morphology ( J:294158 )

• neonates exhibit severe limb defects including limb truncations

short limbs ( J:294158 )

• limb truncations

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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