Phenotypes Associated with This Genotype

Genotype
MGI:6470625

• Allelic Composition: Gt(ROSA)26Sor^{em1(CAG-Zfas1)Cya}/Gt(ROSA)26Sor⁺; Tg(Myh6-cre)#Cya/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

dilated heart left ventricle ( J:294533 )

• increased left ventricular internal dimension at end-diastole (LVIDd) and at systole (LVIDs)

decreased cardiac muscle contractility ( J:294533 )

• decreased ejection fraction (EF) and fractional shortening (FS)

cellular

increased cardiomyocyte apoptosis ( J:294533 )

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:294533 )

• increased resting intracellular Ca²⁺ level in cardiomyocytes

muscle

decreased cardiac muscle contractility ( J:294533 )

• decreased ejection fraction (EF) and fractional shortening (FS)

increased cardiomyocyte apoptosis ( J:294533 )