Phenotypes Associated with This Genotype

Genotype
MGI:6455752

• Allelic Composition: Cic^tm1.1Jip/Cic^tm1.1Jip; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain weight ( J:294338 )

• decreased brain volume by age P14

abnormal dentate gyrus morphology ( J:294338 )

• reduced neuronal density

thin cerebral cortex ( J:294338 )

• at age P14

abnormal cerebellar layer morphology ( J:294338 )

• thin cortex at age P14

mortality/aging

preweaning lethality, complete penetrance ( J:294338 )

• no pups survive beyond age P20-22

growth/size/body

postnatal growth retardation ( J:294338 )

• growth retardation from age P6, severe growth retardation by age P14

• normal size at birth