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Phenotypes Associated with This Genotype
Genotype
MGI:6452819
Allelic
Composition		 Nubp2tm1c(EUCOMM)Hmgu/Nubp2tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (1062 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Nubp2tm1c(EUCOMM)Hmgu mutation (0 available); any Nubp2 mutation (15 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
increased cranial neural crest cell apoptosis ( J:284772 )
• reduced +GFP craniofacial neural crest cells in nasal prominences and pharyngeal arches due to increased apoptosis between E9.5 and E10.5

cellular
increased cranial neural crest cell apoptosis ( J:284772 )
• reduced +GFP craniofacial neural crest cells in nasal prominences and pharyngeal arches due to increased apoptosis between E9.5 and E10.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory