Phenotypes Associated with This Genotype

Genotype
MGI:6452499

• Allelic Composition: Ndc80^tm1Tski/Ndc80^tm1Tski; Tg(Zp3-cre)3Mrt/0
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

aneuploidy ( J:292307 )

• aberrant anaphase I in oocytes results in egg aneuploidies

abnormal meiotic spindle assembly checkpoint ( J:292307 )

• oocytes undergo aberrant anaphase I accompanied by degradation of securing, indicating spindle checkpoint defects; aberrant anaphase results in egg aneuploidies

abnormal meiotic spindle morphology ( J:292307 )

• the microtubule mass undergoes dynamic and aberrant shape changes in oocytes and fails to establish a stable bipolar-shaped spindle during meiosis I, resulting in severe kinetochore-microtubule attachment defects, with some chromosomes falling off the microtubule mass

• although oocytes frequently establish a stable bipolar-shaped spindle in meiosis II, bipolar-shaped spindles exhibit massive chromosome misalignment in metaphase II

reproductive system

abnormal meiotic spindle assembly checkpoint ( J:292307 )

• oocytes undergo aberrant anaphase I accompanied by degradation of securing, indicating spindle checkpoint defects; aberrant anaphase results in egg aneuploidies

abnormal meiotic spindle morphology ( J:292307 )

• the microtubule mass undergoes dynamic and aberrant shape changes in oocytes and fails to establish a stable bipolar-shaped spindle during meiosis I, resulting in severe kinetochore-microtubule attachment defects, with some chromosomes falling off the microtubule mass

• although oocytes frequently establish a stable bipolar-shaped spindle in meiosis II, bipolar-shaped spindles exhibit massive chromosome misalignment in metaphase II