Phenotypes Associated with This Genotype

Genotype
MGI:6452095

• Allelic Composition: Pld4^tm1.2Nemz/Pld4^tm1.2Nemz
• Genetic Background: B6.129(Cg)-Pld4^tm1.1Nemz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:281205 )

thrombocytopenia ( J:281205 )

• in peritoneum

abnormal leukocyte cell number ( J:281205 )

• elevated blood monocyte count

• splenic dendritic cell number

decreased B-1 B cell number ( J:281205 )

• in peritoneum

increased marginal zone B cell number ( J:281205 )

decreased NK T cell number ( J:281205 )

increased monocyte cell number ( J:281205 )

• in blood

abnormal peritoneal macrophage morphology ( J:281205 )

• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages

• CD86 expression

homeostasis/metabolism

increased circulating CXCL10 level ( J:281205 )

• elevated plasma CXCL10 levels

increased circulating interferon-gamma level ( J:281205 )

immune system

immune system phenotype ( J:281205 )

N • normal thioglycolate-elicited IL6 expression in macrophages in response to A-type CpG ODN 2216PS

enlarged spleen ( J:281205 )

abnormal leukocyte cell number ( J:281205 )

• elevated blood monocyte count

• splenic dendritic cell number

decreased B-1 B cell number ( J:281205 )

• in peritoneum

increased marginal zone B cell number ( J:281205 )

decreased NK T cell number ( J:281205 )

increased monocyte cell number ( J:281205 )

• in blood

abnormal peritoneal macrophage morphology ( J:281205 )

• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages

• CD86 expression

increased circulating CXCL10 level ( J:281205 )

• elevated plasma CXCL10 levels

increased circulating interferon-gamma level ( J:281205 )

growth/size/body

enlarged spleen ( J:281205 )

mortality/aging

mortality/aging ( J:281205 )

N • resistant to experimental autoimmune encephalomyelitis